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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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[NTR] neuronal-restricted precursor #2437

Open ANiknejad opened 1 month ago

ANiknejad commented 1 month ago

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl --> not available

Preferred term label neuronal-restricted precursor

Synonyms (add reference(s), please) NRP

https://singlecell.broadinstitute.org/single_cell/study/SCP263/aging-mouse-brain#study-summary

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX) https://link.springer.com/chapter/10.1007/978-1-59259-107-7_5 'populations of restricted progenitors isolated from the embryonic spinal cord and the neonatal forebrain anterior subventricular zone (SVZa), which are committed to the production of neurons and are therefore called neuronal restricted progenitors (NRPs).

but also https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2018.00104/full --> 'More recently, it has been shown that the adult human hypothalamus contains four distinct populations of cells that express neuronal progenitor markers, each of these cell types, with the exception of tanycytes, are human-specific (Pellegrino et al., 2018).

Tricky to define 'neuronal-restricted precursor', in the reference cited above (Pellegrino et al., 2018), we see: 'neural stem/progenitor cell (NPC)'

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl) is_a: CL:0011026 ! progenitor cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon) UBERON:0000955 ! brain

Your ORCID https://orcid.org/0000-0003-3308-6245

Additional notes or concerns This issue is related to the 'Atlas of the Aging Mouse Brain' https://singlecell.broadinstitute.org/single_cell/study/SCP263/aging-mouse-brain#study-summary that reports cell types, some of them not (yet?) in CL/UBERON

AvolaAmg commented 1 month ago

Thank you for your ticket Anne, I will review it shortly and proceed to add the term.

Best, Alida

AvolaAmg commented 2 weeks ago

@Caroline-99 please review definition.

term label:
neuronal-restricted precursor

definition:
A progenitor cell of the central nervous system that differentiates exclusively onto neurons. This progenitor cell is found in a hippocampus subventricular zone, developing cortex and spinal cord. database_cross_reference:

comments: in vitro cultures of mice neural tubes, Neural-restricted precursors are derived by multipotent neuroepithelial cells to give rise to neurons suggesting a linear relationship between multipotent and neural-restricted differentiation (Mayer-Proschel et al., 1997). In the spinal cord of rats, neural-restricted precursor cells give rise cholinergic, GABAergic, glutametergic neurons (Cao and Howard et al., 2002) https://www.sciencedirect.com/science/article/pii/S0014488602979811 database_cross_reference:

has related synonym
NRP
database_cross_reference: PMID: 12429182

Logical definition
progenitor cell
(neuron associated cell (sensu Vertebrata)andpart of somecentral nervous systemUBERON)

parent term:
progenitor cell
[neuron associated cell](sensu vertebrata)[http://purl.obolibrary.org/obo/CL_0000123]