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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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[NTR] candelabrum cell #2446

Closed AvolaAmg closed 3 weeks ago

AvolaAmg commented 4 months ago

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label

Synonyms (add reference(s), please)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Your ORCID

Additional notes or concerns

dosumis commented 2 months ago

Related GO term candelabrum cell differentiation http://purl.obolibrary.org/obo/GO_0021712

Draft extended description from perplexity using standard CellGuide prompt:

https://www.perplexity.ai/search/system-role-you-are-a-knowledg-.y1IafRsT3KFBcCcGUlM1Q

AvolaAmg commented 1 month ago

Definition:

A GABAergic interneuron located in the cerebellar cortex. This GABAergic interneuron type has a distinct morphology, it presents a small cell soma near the Purkinje cell layer (PCL), dendrites that extend to the surface of the molecular layer, and beaded axons that make local synapses contacts within the molecular layer. A candelabrum cell is excited by mossy fibers and granule cells but inhibited by Purkinje cells, and it inhibits molecular layer interneurons, which leads to the disinhibition of Purkinje cells.

reference: PMID: 35578131

extended definition:

Candelabrum cells are the most abundant interneurons in the Purkinje cell layer and are present in all cerebellar lobules.

reference: PMID: 35578131

Synonym: CC reference: PMID: 35578131

synonym: candelabrum interneuron reference: PMID: 35578131

@JABelfiore please review