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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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[NTR] BEST2+ Goblet cell #2518

Closed JABelfiore closed 1 month ago

JABelfiore commented 2 months ago

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label BEST2+ Goblet cell

Synonyms (add reference(s), please)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX) A specialized goblet cell in the colon that expresses the bestrophin-2 (Best2) protein on their basolateral membrane. This cell plays a crucial role in bicarbonate transport and mucus secretion, contributing to the maintenance of colonic pH and hydration PMID:34497389 PMID: 20407206 PMID: 24223998

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl) goblet cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Your ORCID epithelium

Additional notes or concerns

JABelfiore commented 1 month ago

Closing as agreed we don't need separate cell type for BEST2 goblet cells in the colon as it marks all goblet cells in the colon