search

obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
Creative Commons Attribution 4.0 International
142 stars 49 forks source link

Disease associated cells #2525

Open jychien opened 2 weeks ago

jychien commented 2 weeks ago

We were wondering if disease associate cell types should have their own CL term. Ones that we've come across:

Many immune cells are a response to disease, so we were curious if these cell type were distinct enough to warrant a new CL term.

aleixpuigb commented 2 weeks ago

Hi Jennifer,

The Cell Ontology primarily focuses on 'native cell', i.e. the normal cells of a healthy organism. Although we have few cell types under 'abnormal cell' (CL:0001063), in the past there were requests for tumor-associated cells, and in those cases it was finally decided that they were not going to be added. https://github.com/obophenotype/cell-ontology/issues/1471 https://github.com/DiseaseOntology/HumanDiseaseOntology/issues/1016 https://github.com/obophenotype/cell-ontology/issues/448

AFAIK the reasons for not adding the terms are still valid, but I will CC @addiehl @dosumis @cmungall for their input.