addiehl
commented
1 month ago We should probably drop the (in_taxon some Mammalia) for the B cell, CD19-positive. According to this article, CD19 is found on B cells in Zebrafish, and is thus most like a marker of B cells in most or all vertebrates.
Google Gemini offers up additional articles in support of CD19 on B cells in zebrafish. I have not had time to verify this information yet:
Scientific Articles Identifying CD19 as a B Cell Marker in Zebrafish
Here are a few scientific articles that have used CD19 as a marker for B cells in zebrafish:
- Page et al., 2013: This study characterized the development and behavior of IgM+ B cells in zebrafish. They utilized three fluorescent transgenic lines, including one expressing CD19, to define the existence of pro-B, immature/mature, and mature B cells in the kidney marrow.
Title: "Zebrafish B cells exhibit a distinct developmental pattern and are highly plastic." Journal: Blood
- Lu et al., 2016: This research explored the role of B cells in zebrafish tumor immunity. They found that CD19+ B cells can express the death ligand FasL to directly induce cytotoxicity when stimulated by IL-17A.
Title: "CD19+ B cells contribute to anti-tumor immunity in zebrafish through FasL-mediated cytotoxicity." Journal: Frontiers in Immunology
- Hu et al., 2010: This study identified IgZ as a novel B cell marker in zebrafish. They also confirmed the expression of CD19 on B cells in different tissues.
Title: "Identification of IgZ as a novel B cell marker and its expression in zebrafish immune tissues." Journal: Developmental and Comparative Immunology
- Tao et al., 2017: This research investigated the regulatory role of B cells in zebrafish inflammation. They found that CD19+ B cells can be negatively regulated by IL-10.
Title: "IL-10-producing B cells regulate inflammation in zebrafish." Journal: Journal of Immunology These articles provide valuable insights into the use of CD19 as a B cell marker in zebrafish and its role in various immune processes.
dosumis
Two CL terms have taxon constraints that are too tight and cause issues when ZFA is merged with Uberon and CL.
'B cell, CD-19 positive'
'B cell, CD-19 positive' is said to be mammal-specific (in_taxon some Mammalia). It’s actually part of the logical definition.
This makes, in turn, most of the B cells in CL (e.g. 'mature B cell', 'immature B cell', 'transitional stage B cell, etc.) mammal-specific.
But B cells (including mature and immature B cells, transitional stage B cell, etc.) exist beyond mammals, e.g. in zebrafish. Most ZFA terms for B cells are unsatisfiable in Uberon+CL+ZFA because of the restriction of 'B cell, CD-19 positive' to mammals.
'rod bipolar cell'
'rod bipolar cell is said to be mammal-specific (in_taxon some Mammalia).
But those cells apparently also exist in zebrafish, and the ZFA term for them is unsatisfiable in Uberon+CL+ZFA because of that restriction to mammals.