[NTR] Mesenchymal lymphoid tissue organizer cell

[JABelfiore]

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label Mesenchymal lymphoid tissue organizer cell

Synonyms (add reference(s), please)

mLTo cells [PMID:31201308]

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

A stromal cell found in the adult gut that plays a crucial role in the formation and maintenance of gut-associated lymphoid tissues (GALTs). This cell is characterized by it's ability to interact with lymphoid tissue inducer (LTi) cells, express lymphotoxin beta receptor (LTβR) and vascular cell adhesion molecule (VCAM), produce chemokines and cytokines for immune cell recruitment and positioning, and contribute to the structural organization of lymphoid tissues within the intestinal environment. mLTo cells are distinguished from other stromal cells by their specific function in orchestrating the development and maintenance of organized lymphoid structures in the gut, which are essential for intestinal immune responses and homeostasis. PMID: 34497389

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

Mesenchymal progenitor cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Your ORCID https://orcid.org/0009-0005-7919-4905

Additional notes or concerns

[dosumis]

Doesn't look quite right we need cell in adult gut.

[dosumis]

https://www.perplexity.ai/search/what-is-known-about-the-sturct-BEDqQGfIRHK3MOx_1NEbNA

[dosumis]

actually got a slightly more relevant looking answer on the second question here: https://www.perplexity.ai/search/provide-mlto-fibroblasts-tBBLTiRmRmua3PfUubhsKg

(ignore first)