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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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[NTR] Molecular layer interneurons #2668

Closed AvolaAmg closed 2 weeks ago

AvolaAmg commented 1 month ago

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label

Synonyms (add reference(s), please)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Your ORCID

Additional notes or concerns

Request: new term Preferred term label: Molecular layer interneurons Synonyms: MLI (PMID: 33075461, PMID: 38692278, PMID: 34616064), ML (PMID: 30742002) Definition: Molecular layer interneurons are spontaneously active interneurons that inhibit Purkinje cells as well as other MLIs. MLIs are canonically subdivided into stellate cells located in the outer third of the molecular layer, and basket cells located in the inner third of the molecular layer that synapse onto Purkinje cell somata and form specialized contacts known as pinceaus, which ephaptically inhibit Purkinje cells. (PMID: 34616064) Parent cell type term: GABAergic interneuron (CL:0011005), cerebellar neuron (CL:1001611), CNS interneuron(CL:0000402), cerebellar inhibitory GABAergic interneuron (CL:4023057) Anatomical structure where the cell type is found: cerebellum (UBERON:0002037) Child term: cerebellum basket cell (CL:2000027), cerebellar stellate cell (CL:0010010) Additional notes or concerns: This term to group cerebellar basket and stellate cells together seems mentioned enough in the literature to have its own term in CL.

AvolaAmg commented 3 weeks ago

improved definition: A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons.

parent cell term: cerebellar inhibitory GABAergic interneuron (CL:4023057)

has a related synonym: MLI (PMID: 33075461, PMID: 38692278, PMID: 34616064), ML (PMID: 30742002)