Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A CD8 T cell characterized by high expression of Granzyme K (GZMK). This cell is enriched in inflamed tissues, including synovial tissue in rheumatoid arthritis, the gut, kidneys, and respiratory tissues during conditions like COVID-19. Unlike highly cytotoxic GZMB+ CD8+ T cell, GZMK+ CD8+ T cell exhibits lower direct cytotoxic potential, and is involved producing pro-inflammatory cytokines such as IFN-γ and TNF-α.
Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl
Preferred term label granzyme K-associated CD8 T cell
Synonyms (add reference(s), please) granzyme K+ CD8 T cell - exact synonym PMID: 35704599 tissue-enriched expressing GzmK CD8 cell - exact synonym PMID: 35704599 TteK CD8 cell - exact synonym PMID: 35704599 GZMKhigh CD8+ T effector memory cell -Narrow synonym/related? PMID: 36347862
Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX) A CD8 T cell characterized by high expression of Granzyme K (GZMK). This cell is enriched in inflamed tissues, including synovial tissue in rheumatoid arthritis, the gut, kidneys, and respiratory tissues during conditions like COVID-19. Unlike highly cytotoxic GZMB+ CD8+ T cell, GZMK+ CD8+ T cell exhibits lower direct cytotoxic potential, and is involved producing pro-inflammatory cytokines such as IFN-γ and TNF-α.
PMID: 35704599 PMID: 37449888
Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl) CD8-positive, alpha-beta memory T cell
Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
Your ORCID
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