[NTR-cxg] neuromuscular junction

[sebozzie]

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label neuromuscular junction

Synonym(s) (add reference(s), please) neuromuscular junction nuclei https://doi.org/10.1038/s41467-020-20063-w NMJ https://doi.org/10.1038/s41467-020-18789-8 NMJ nuclei https://doi.org/10.1038/s41467-020-20064-9 - PMID: 33311457 NMJ myonuclei - PMID:33311464

Definition Neuromuscular junction nuclei are specialized muscle nuclei located at the synapse where a motor neuron communicates with a muscle fiber. They regulate the production of proteins essential for maintaining the structure and function of the neuromuscular junction, supporting efficient nerve-muscle signaling for muscle contraction.

Parent cell type term CL:0008046: extrafusal muscle fiber

Anatomical structure where the cell type is found UBERON:0001134: skeletal muscle tissue

Your ORCID 0009-0001-6947-615X

Additional notes or concerns

https://doi.org/10.1038/s41467-020-20063-w: "NMJ nuclei were positive for known canonical markers such as Chrne, Etv5, Colq, and Musk..."

[dosumis]

Given the suggestion of 'CL:0008046; extrafusal muscle fiber' as a parent I assume that this term is intended for skeletal muscle NMJ nuclei is that correct?

suggested label: skeletal nueuromuscular junction nucleus (?) Suggested EC def: 'GO:nucleus and part_of some 'CL:0008046; extrafusal muscle fiber' and overlaps some ' GO:0098523; neuromuscular junction of myotube'

[sebozzie]

@dosumis Indeed, it is intended for skeletal muscle NMJ nuclei. In that case I would suggest the label "neuromuscular junction nuclei" or "NMJ nuclei".

[Caroline-99]

Hi @sebozzie. The new term 'neuromuscular junction nucleus (CL:4052025)' will be included in the next CL release. The terms "neuromuscular junction nuclei" and "NMJ nuclei" have been added as synonyms. Thank you.