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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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[Class hierarchy] T-types with reference clusters that do not subsume each other should not be subclasses of each other #2721

Open dosumis opened 3 weeks ago

dosumis commented 3 weeks ago

Lamp5 Lhx6 neuron SubClassOf Lamp 5 neuron, but transcriptomically they are distinct:

image

https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/

Another way to think about this is that if these two classes were defined with suitably specific marker sets derived from the transcriptomics data, they would not subsume each other.