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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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mammary stem cell #290

Closed cmungall closed 9 years ago

cmungall commented 14 years ago

Mammary stem cells provide the source of cells for growth of the mammary gland during puberty and gestation and play an important role in carcinogenesis of the breast.[9] Mammary stem cells have been isolated from human and mouse tissue as well as from cell lines derived from the mammary gland. Single such cells can give rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice.[9]

9: Liu S, Dontu G, Wicha MS (2005). "Mammary stem cells, self-renewal pathways, and carcinogenesis". Breast Cancer Research 7 (3): 86–95. doi:10.1186/bcr1021. PMID 15987436.

is_a stem cell; CL:

Appear to have specific cell surface markers:Lin-,CD24+, CD29hi

see also Shackleton et al., 2006; Stingl et al., 2006). Shackleton, M., Vaillant, F., Simpson, K.J., Stingl, J., Smyth, G.K., Asselin- Labat, M.L., Wu, L., Lindeman, G.J., and Visvader, J.E. (2006). Generation of a functional mammary gland from a single stem cell. Nature 439, 84–88. Stingl, J., and Caldas, C. (2007). Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat. Rev. Cancer 7, 791–799.

Original comment by: hdrabkin

cmungall commented 14 years ago

CL:0002451. made a child of 'multi-fate stem cell'.

Original comment by: tmeehan

cmungall commented 14 years ago

Original comment by: tmeehan