Open cerivs opened 8 years ago
and ('has plasma membrane part' some 'urokinase plasminogen activator surface receptor') The mechanism is different in teleost so this is not a true statement PMID 22733817
and ('has plasma membrane part' some 'carcinoembryonic antigen-related cell adhesion molecule 8') Protein/gene has not been identified in zebrafish.
(originally reported by @cerivs )
@addiehl The logical definition of granulocyte CL:0000094 seems quite stringent:
'myeloid leukocyte' and ('has part' some 'secretory granule') and ('has plasma membrane part' some 'integrin alpha-M') and ('has plasma membrane part' some 'carcinoembryonic antigen-related cell adhesion molecule 8') and ('has plasma membrane part' some 'urokinase plasminogen activator surface receptor') and ('capable of' some 'blood circulation') and (lacks_plasma_membrane_part some 'CD19 molecule') and (lacks_plasma_membrane_part some 'CD3 epsilon') and (lacks_plasma_membrane_part some 'neural cell adhesion molecule 1') and (lacks_plasma_membrane_part some 'T-cell surface glycoprotein CD8 alpha chain')
If the term as is was meant for human/mammals, we should add a taxon constraint and clarify in label/def. If so, is a broader class needed that's applicable to fish too?
The granulocytes in general need a major curation effort. I have been thinking about this for awhile, but it would be a serious commitment of time, so I have not started yet.
We still need a generic granulocyte grouping class to accommodate the differences in fish.
and ('has plasma membrane part' some 'urokinase plasminogen activator surface receptor')
The mechanism is different in teleost so this is not a true statement PMID 22733817
and ('has plasma membrane part' some 'carcinoembryonic antigen-related cell adhesion molecule 8') Protein/gene has not been identified in zebrafish.