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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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Are APUD (amine precursor uptake and decarboxylation) cells always NC-derived? #446

Closed cmungall closed 2 years ago

cmungall commented 8 years ago

Text def:

A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell.

This isn't reflected in the axioms. If we believe it, we should add SubClassOf develops-from 'neural crest cell (or a sub-population). If we don't we should change the text. Overall we need more reflection of the text in axioms.

This is the reference: http://www.abebooks.com/book-search/isbn/0721662544/ (Dorlands)

gouttegd commented 2 years ago

WARNING: This issue has been automatically closed because it has not been updated in more than 3 years. Please re-open it if you still need this to be addressed – we are now getting some resources to deal with such issues.