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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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Definition update for CL_0000178 #471

Closed cerivs closed 2 years ago

cerivs commented 7 years ago

: A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.

Please change to A Leydig cell is a cell capable of secreting testosterone in the interstitial area, between the seminiferous tubules, in the testis.

Zebrafish Ledig cells secrete 11-Keto-Testosterone https://en.wikibooks.org/wiki/The_Zebrafish_in_Toxicology/Testis_location "Leydig cells are the source of androgens. In teleosts, they produce 11-ketotestosterone under complex regulation. Androgen production in teleosts is stimulated by the pituitary derived gonadotropin, and gonadotropin production is partly under feedback control of plasma androgen levels" cites PMID: 7981031
11-Keto-testosterone https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:34133 Right now testosterone secretion in GO references https://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:17347

We might need some changes in GO too and maybe Changes in the CHEBI hierarchy to make 11-Keto-testosterone a steroid hormone .

gouttegd commented 2 years ago

WARNING: This issue has been automatically closed because it has not been updated in more than 3 years. Please re-open it if you still need this to be addressed – we are now getting some resources to deal with such issues.