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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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[NTR] CD3+ T cell #666

Closed nicolevasilevsky closed 4 years ago

nicolevasilevsky commented 4 years ago

Preferred term label: 'CD3-positive, alpha-beta T cell'

Synonyms CD3-positive, alpha-beta T lymphocyte CD3-positive, alpha-beta T-cell CD3-positive, alpha-beta T-lymphocyte CD3+ T cell

Definition (free text, please give PubMed ID) A T cell expressing an alpha-beta T cell receptor and the CD3 coreceptor.

'mature alpha-beta T cell' and ('has plasma membrane part' some 'CD3 subunit with immunoglobulin domain')

Parent term 'mature alpha-beta T cell'

related ticket: https://github.com/obophenotype/human-phenotype-ontology/issues/5701

@addiehl does this look okay to you?

addiehl commented 4 years ago

We do not need this term. The alpha-beta T cell receptor contains the CD3 chains by default -- they are part of the TCR protein complex.

addiehl commented 4 years ago

Beyond which, all mature T cells are CD3+, because CD3 is a component of the gamma-delta TCR complex as well. Also, when people say CD3+, they really mean CD3e positive, because that is the CD3 chain that is almost always targeted in a flow cytometry assay.

nicolevasilevsky commented 4 years ago

Thanks, Alex and thanks for your comment on the HPO ticket. We can close this.