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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
Creative Commons Attribution 4.0 International
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stem cell #97

Open GoogleCodeExporter opened 9 years ago

GoogleCodeExporter commented 9 years ago 
stem cell is defined as:
"A relatively undifferentiated cell that retains the ability to divide and 
proliferate throughout life to provide progenitor cells that can differentiate 
into specialized cells."

This fits with the broad usage of this term. But a more specialised usage, 
which some people insist is the correct one, defines a stem cell as a precursor 
cell that is capable of dividing (budding off progeny) while retaining its 
identity.

In order to allow for both usages, I propose addition of a new term 'stem cell 
(sensu strictu)' which has the more specialised definition. I think that this 
is useful as there may well be things that stem cells in this strict sense have 
in common.  This term is also amenable to formal definition and therefore use 
in auto-classification, where the broadly defined term is probably not.

Original issue reported on code.google.com by dosu...@gmail.com on 26 Sep 2013 at 2:56

paolaroncaglia commented 2 years ago

The changes that @dosumis suggested haven't been implemented. Commenting to prevent staleness as the suggestions are about a high-level term.

addiehl commented 2 years ago

There needs to be larger revision and standardization to how CL defines and places stem cells, precursor cells, progenitor cells, and immature cells in the hierarchy. The whole area requires some serious curation.

paolaroncaglia commented 2 years ago

There needs to be larger revision and standardization to how CL defines and places stem cells, precursor cells, progenitor cells, and immature cells in the hierarchy. The whole area requires some serious curation.

Shall we convert this ticket to an Epic?