reconcile HPO age of onset terms with HsapDv

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Many of the classes in HPO do not temporally align with HsapDV. 

For example:
HPO 'Young adult onset': Onset of disease at the age of between 15 and 40 years.
HsapDv 'Young adult stage': Early adulthood that refers to an adult who is 
under 25.

We need a plan, lets discuss.

Original issue reported on code.google.com by haen...@ohsu.edu on 3 Mar 2014 at 9:59

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I have nothing against the principle of aligning with another resource. But we 
need to discuss the biology behind the terms.

In HsapDV, the rational was: 
- HsapDv:0000086 13-18 years: to capture the puberty period. 
- HsapDv:0000089 19-24 years: we defined 25 yo as an arbitrary threshold, to 
capture the fact that around this age, some biological functions or structures 
start declining, or a least, stop developing. 
- HsapDv:0000090 25-44 years: we defined 45 yo as an arbitrary threshold based 
mostly on woman menopause. 

So I guess that, in HPO, they defined 15 yo as the age of sexual maturity, 40 
yo being the same kind of arbitrary threshold we used with woman menopause? 
I think we could be OK with that, but then we would loose the puberty period, 
and for creating a sub-stage 19-24 years, I would need a sub-stage 15-18 years, 
which wouldn't have any biological meaning. 

Original comment by frederic...@gmail.com on 4 Mar 2014 at 3:44

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I think that HPO should define adulthood either starting at 15 or 20, because 
they currently have an inconsistency:

'Adult onset' is defined as: Onset of disease manifestations in adulthood, 
defined here as at the age of 20 years or later.
subClass 'Young adult onset' defined as: Onset of disease at the age of between 
15 and 40 years.

I actually prefer 18, perhaps we can suggest that in between age. 
see: https://sourceforge.net/p/obo/human-phenotype-requests/273/

Original comment by haen...@ohsu.edu on 4 Mar 2014 at 3:51

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Would you have a link for me to access the stages defined by the Oxford 
Clinical Genetics handbook?

Also, why 18? It sounds more like a social convention to me.

Original comment by frederic...@gmail.com on 4 Mar 2014 at 8:06

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It seems HPO's "young adult" (now 16-40) best maps to "human early adulthood 
stage" (19-44).

I don't know if we need to match exactly, things can be reconciled via age 
properties, but if we decide not to align we should come up with some kind of 
suffix for the obo-foundry-unique-synonym, preferably referencing some 
established system.

Given that these are arbitrary semi-social groupings it seems there's nothing 
to be gained by maintaining non-aligned intervals, keeps things simplest to 
just match.

Original comment by cmung...@gmail.com on 12 Mar 2014 at 10:37

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I agree with the principle of aligning, but not really happy with their stages 
around sexual maturity/puberty. Would they accept some reasonable suggestions 
of changes, or it's not an option?

Could you please list the required modifications to align, so that I can 
discuss them with Anne and Marc? It might require some reannotations on our 
side :/

Original comment by frederic...@gmail.com on 13 Mar 2014 at 1:20

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Perhaps add a pubescent stage, from say 12-15? that could be a subclass of 
juvenile?

Original comment by haen...@ohsu.edu on 6 Jul 2014 at 11:02