pnrobinson
commented
2 months ago @MickeySegal the HPO wants to extend out to pathological findings and has one new branch Biospecimen phenotypic feature This branch is appropriate if one is phenotyping a tumor or biospecimen. If one is recording the observation of a Krukenberg tumor in a patient, then the following term would be appropriate
Krukenberg tumor def: Krukenberg tumor is a metastatic signet-ring cell adenocarcinoma of the ovary characterized by mucin-rich, signet-ring cells. comment: Krukenberg tumors originate from a gastrointestinal primary in 70% of cases, but also involving the colon, breast, appendix, and biliary tract. Krukenberg tumor is characterized by mucin-laden signet ring cells with offset, hyperchromatic nuclei. The cytoplasmic mucin within signet ring cells is necessary for diagnosis. The cytoplasm of the signet ring cells may be diffusely granular with eosinophilic bodies, largely vacuolated, or a combination featuring a large vacuole containing a drop of mucin, creating an eosinophilic body. Many patterns of signet ring cell organization are possible even within the same tumor. PMID: 29489206
It is probably better to go with the above term for now, since the pathology findings will be a big lift and we want to do it systematically with workshops. Thoughts?
MickeySegal
Preferred term label: Tumor signet ring cells
Synonyms
Definition (free text, please give PubMed ID) An example is https://www.ncbi.nlm.nih.gov/medgen/?term=C1335170
Parent term (use hpo.jax.org/app) HPO has https://hpo.jax.org/app/browse/term/HP:0032175, which has a very similar name but an unrelated concept.
Diseases characterized by this term ? (e.g. Orphanet or OMIM number) https://www.ncbi.nlm.nih.gov/books/NBK482284/
Your nano-attribution (ORCID)