pnrobinson
commented
3 months ago @GrieseAG Although this is a well recognized phenomenon, the HPO dies not encode etiologies. The way to encode this for a patient would be to encode with terms for Anemia and another term for Failure to increased EPO.
These are the EPO terms we have now Abnormal circulating erythropoietin concentration HP:0034442
What about a new term
Inappropriate normal or low erythropoietin Def: Erythropoietin is produced and released into the blood by the kidneys in response to hypoxemia, and would normally be expected to increase with decreasing hemoglobin levels. This term applies if the increase fails to occur, as may be seen in conditions including chronic kidney disease.
GrieseAG
Preferred term label: Renal anemia
Synonyms
Definition (free text, please give PubMed ID) https://doi.org/10.1016/j.semnephrol.2006.06.001
Anemia due to renal disease. Anemia is a common complication of chronic kidney disease. Although mechanisms involved in the pathogenesis of renal anemia include chronic inflammation, iron deficiency, and shortened half-life of erythrocytes, the primary cause is deficiency of erythropoietin (EPO). Serum EPO levels in patients with chronic kidney disease are usually within the normal range and thus fail to show an appropriate increase with decreasing hemoglobin levels, as found in nonrenal anemias. As with other anemias, the consequences of renal anemia are a moderate decrease in tissue oxygen tensions and counterregulatory mechanisms that maintain total oxygen consumption, including a persistent increase in cardiac output.
Parent term (use hpo.jax.org/app) HP:0001903: Anemia
Diseases characterized by this term ? (e.g. Orphanet or OMIM number)
Your nano-attribution (ORCID) 0000-0003-0113-912X, 0000-0002-7371-8158