obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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Hypolacrimia #10853

Closed carolina-f closed 3 weeks ago

carolina-f commented 4 weeks ago

HPO term Decreased lacrimation HP:0000633

Synonym to be added Hypolacrimia

broad/exact/narrow/plural/abbreviation ? PMID: 35925585 As part of the lacrimal apparatus, the lacrimal gland participates in the maintenance of a healthy eye surface by producing the aqueous part of the tear film. Alacrimia and hypolacrimia, which are relatively rare during childhood or young adulthood, have their origin in a number of mechanisms which include agenesia, aplasia, hypoplasia, or incor- rect maturation of the gland. Moreover, impaired innervation of the gland and/or the cornea and alterations of protein secretion pathways can lead to a defective tear film. In most conditions leading to alacrimia or hypolacrimia, however, the altered tear film is only one of numerous defects that arise and therefore is commonly disregarded.

pnrobinson commented 3 weeks ago

added, thank you!