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Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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Hypermyelination #280

Closed obophenotype-user closed 9 years ago

obophenotype-user commented 10 years ago

Hello,

Can the term "hypermyelination" be added to this branch on the ontology [HP:0011400] Abnormal CNS myelination where the corresponding term "hypomyelination" is found?

Proposed definition: Increased amount of myelin in the nervous system usually resulting in a thicker myelin sheath

Thank you, Heather Trang, PhenoTips team member

Reported by: heathertrang

Original Ticket: obo/human-phenotype-requests/280

obophenotype-user commented 10 years ago

Original comment by: pnrobinson

obophenotype-user commented 10 years ago

Could you specify whether you mean CNS or peripheral or both? I have not seen any descriptions of CNS hypermyelination yet, and for peripheral, there does not seem to be diffuse hypermyelination, but rather focal areas of hypermyelination that have been called tomacula:

http://www.sciencedirect.com/science/article/pii/0022510X75902634?via=ihub

Please let me know the use case.

Original comment by: pnrobinson

obophenotype-user commented 10 years ago

Hi Peter,

This term request came from the NIH UDP group - I will connect with them regarding your questions and let you know.

Sincerely, Heather

On Sat, Mar 22, 2014 at 1:55 PM, Peter N. Robinson probins@users.sf.netwrote:

  • status: unread --> pending
  • _assignedto: Peter N. Robinson
  • Comment:

Could you specify whether you mean CNS or peripheral or both? I have not seen any descriptions of CNS hypermyelination yet, and for peripheral, there does not seem to be diffuse hypermyelination, but rather focal areas of hypermyelination that have been called tomacula:

http://www.sciencedirect.com/science/article/pii/0022510X75902634?via=ihub

Please let me know the use case.

Status: pending

Group: musculoskeletal Created: Fri Mar 21, 2014 06:43 PM UTC by Heather Trang Last Updated: Fri Mar 21, 2014 06:43 PM UTC Owner: Peter N. Robinson

Hello,

Can the term "hypermyelination" be added to this branch on the ontology [HP:0011400] Abnormal CNS myelination where the corresponding term "hypomyelination" is found?

Proposed definition: Increased amount of myelin in the nervous system usually resulting in a thicker myelin sheath

Thank you,

Heather Trang, PhenoTips team member

Sent from sourceforge.net because you indicated interest in https://sourceforge.net/p/obo/human-phenotype-requests/280/

To unsubscribe from further messages, please visit https://sourceforge.net/auth/subscriptions/

Original comment by: heathertrang

obophenotype-user commented 10 years ago

Hi Peter,

I asked the NIH team about their use of the term hypermyelination. According to their response, they make note of when hypermyelination is observed on CNS MRI imaging. This is noted to be global in some patients and focal in others. Is this sufficient clarification for terms to be created?

Thank you, Heather

On Fri, Mar 28, 2014 at 11:44 AM, Heather Trang heathertrang@users.sf.netwrote:

Hi Peter,

This term request came from the NIH UDP group - I will connect with them regarding your questions and let you know.

Sincerely, Heather

On Sat, Mar 22, 2014 at 1:55 PM, Peter N. Robinson probins@users.sf.net wrote:

  • status: unread --> pending
  • _assignedto: Peter N. Robinson
  • Comment:

Could you specify whether you mean CNS or peripheral or both? I have not seen any descriptions of CNS hypermyelination yet, and for peripheral, there does not seem to be diffuse hypermyelination, but rather focal areas of hypermyelination that have been called tomacula:

http://www.sciencedirect.com/science/article/pii/0022510X75902634?via=ihub Please let me know the use case.

Status: pending

Group: musculoskeletal Created: Fri Mar 21, 2014 06:43 PM UTC by Heather Trang Last Updated: Fri Mar 21, 2014 06:43 PM UTC Owner: Peter N. Robinson

Hello,

Can the term "hypermyelination" be added to this branch on the ontology [HP:0011400] Abnormal CNS myelination where the corresponding term "hypomyelination" is found?

Proposed definition: Increased amount of myelin in the nervous system usually resulting in a thicker myelin sheath

Thank you,

Heather Trang, PhenoTips team member

Sent from sourceforge.net because you indicated interest in https://sourceforge.net/p/obo/human-phenotype-requests/280/

To unsubscribe from further messages, please visit https://sourceforge.net/auth/subscriptions/

Status: pending Group: musculoskeletal Created: Fri Mar 21, 2014 06:43 PM UTC by Heather Trang Last Updated: Sat Mar 22, 2014 05:55 PM UTC Owner: Peter N. Robinson

Hello,

Can the term "hypermyelination" be added to this branch on the ontology [HP:0011400] Abnormal CNS myelination where the corresponding term "hypomyelination" is found?

Proposed definition: Increased amount of myelin in the nervous system usually resulting in a thicker myelin sheath

Thank you,

Heather Trang, PhenoTips team member

Sent from sourceforge.net because you indicated interest in https://sourceforge.net/p/obo/human-phenotype-requests/280/

To unsubscribe from further messages, please visit https://sourceforge.net/auth/subscriptions/

Original comment by: heathertrang

obophenotype-user commented 10 years ago

Original comment by: pnrobinson

obophenotype-user commented 10 years ago

Added term CNS hypermyelination, with def: Increased amount of myelin in the central nervous system.

Original comment by: pnrobinson

obophenotype-user commented 10 years ago

Original comment by: pnrobinson

obophenotype-user commented 10 years ago

Added term HP:0012754, CNS hypermyelination

Original comment by: pnrobinson