pnrobinson
commented
6 years ago Sorry for the late response. The HPO includes terms for phenotypes but avoids encoding inferences about the etiology. Neuropathic pain includes a number of components (The wikipedia description is good: https://en.wikipedia.org/wiki/Neuropathic_pain), and the HPO has terms to cover these, e.g., Allodynia (https://hpo.jax.org/app/browse/term/HP:0012533) and Dysesthesia (https://hpo.jax.org/app/browse/term/HP:0012534). The reason for not including etiology in the terms is that if we started down this road we would have to include multiple versions of terms to encode the (assumed) aetiologies; for instance, type I diabetec hyperglycemia, type II diabetic hyperglycemia, steroid-induced hyperglycemia,... Also there is a risk that either the ontology would be wrong or the assumptions of the people coding patients with the ontology would be wrong leading to false inferences. So I would advice coding patients or diseases with the features (such as Allodynia) that led to the inference of Neuropathic pain.
andrewdevereau
submitted on behalf of David Bennett, Professor of neurology and neurobiology, Nuffield department of clinical neurosciences, Uni. of Oxford
For new term requests, please provide us with the following information:
1. Preferred term label
Neuropathic pain
2. Synonyms
3. Textual definition (should be understandable even for non-specialists, please include a PubMed ID for relevant articles providing additional information about the suggestion)
Neuropathic pain is pain arising as a direct consequence of a lesion or disease affecting the somatosensory system. PMID: 18003941 PMID: 27115670
4. Parent term (use HPO Browser or OLS)
Chronic pain HP:0012532
5. Which diseases are characterized by this term ? (e.g. Orphanet- or OMIM-id)
ORPHA:324585 Autosomal dominant intermediate Charcot-Marie-Tooth disease with neuropathic pain
6. Your nano-attribution (ORCID-id or label, e.g. HPO:probinson (organization:name))
https://orcid.org/0000-0002-1089-1543