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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Granuloma #4045

Closed MorganSimiluk closed 5 years ago

MorganSimiluk commented 6 years ago

For new term requests, please provide us with the following information:

1. Preferred term label

Granuloma

2. Synonyms

Granulomatous lesion.

3. Textual definition (should be understandable even for non-specialists, please include a PubMed ID for relevant articles providing additional information about the suggestion)

a mass of granulation tissue, typically produced in response to infection, inflammation, or the presence of a foreign substance.

4. Parent term (use HPO Browser or OLS)

5. Which diseases are characterized by this term ? (e.g. Orphanet- or OMIM-id)

Chronic granulomatous disease

6. Your nano-attribution (ORCID-id or label, e.g. HPO:probinson (organization:name))

pnrobinson commented 6 years ago

It is not obvious where to place this on our current hierarchy because a granuloma can occur nearly anywhere in the body. It is also not "abnormal" immune system physiology (as is the term granulomatous inflammation in MP, which indicates "too much" granuloma formation). I imagine we should probably put this as an abnormal immune morphology. Children, such as liver granuloma can go there and also in their respective organ systems. Because a granuloma needs to be distinguished from an execessive granulomatous response, I would put granuloma under morphology and excessive granuloma formation under physiology. @mellybelly @drseb @cmungall does this make sense?

pnrobinson commented 5 years ago

added. I think this is an Abn immune system morphology -- even if it can be a normal response to an infection we can consider it as abnormal for the time it is present.