Loinc 2336-6: "Globulin [Mass/volume] in Serum"

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Ontology for the description of human clinical features

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Loinc 2336-6: "Globulin [Mass/volume] in Serum" #4214

Closed jpgourdine closed 5 years ago

jpgourdine commented 6 years ago

Suggest creating a new term for Loinc: 2336-6 [Globulin [Mass/volume] in Serum] New term label:Abnormal circulating globulin New term comment (if any):Child term : abnormal beta globulin level HP0025465 Your biocurator ID for loinc2hpo (if desired): OHSU:JP @nicolevasilevsky

pnrobinson commented 5 years ago

I am not sure it makes sense to have this term, since the alpha, beta, gamma globulins in serum are not really related to each other in terms of functionality. What is the use case? I also do not think they are measured together and wonder if this is a legacy term from LOINC?

jpgourdine commented 5 years ago

Hi @pnrobinson , It looks like it Globulin test is still in used. I found here that globlulin test are used for diagnoses of Liver damage or disease, Kidney disease, Nutritional problems, Autoimmune disorders, certain types of cancer. Globulin test are preformed by Serum Protein Electrophoresis or Total Protein test (Albumin/Globulin ration)

jpgourdine commented 5 years ago

Also related, I found one inconsistency on the "Increased antibody level in blood HP:0010702" , "Increased of alpha-globulin HP:0005413" is a child of this term but alpha-globulin are not antibodies see here for the MEsh hierarchy

pnrobinson commented 5 years ago

fixed the alpha-globulin mistake

pnrobinson commented 5 years ago

Adding Abnormal circulating globulin level as HP_0032179