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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Increased circulating arachidonate level #4595

Closed callahantiff closed 5 years ago

callahantiff commented 5 years ago

NTR: Increased circulating arachidonate level

Parent: HP_0045016 Elevated Serum Long-Chain Fatty Acids

For LOINC code: 35168-4 Arachidonate (C20:4w6) [Moles/volume] in Serum or Plasma

Source: PMC6052660

Biocurator ID for loinc2hpo: UCDenver:tjcallahan

pnrobinson commented 5 years ago

Is this the correct parent? https://hpo.jax.org/app/browse/term/HP:0030361

callahantiff commented 5 years ago

That's a good question. I'm not expert here, but it sort of looks like eicosanoids are a product of certain chemical processes that act on arachidonic acid source?

LCCarmody commented 5 years ago

In general, I have been trying to look in CHEBI and find the best parent present in the HPO (and/or create a parent if it is obvious and not present). I have also been adding the logical definitions with CHEBI terms, so when reasoning, they should move to their correct positions. We may need a few parent terms once all of these are in there. At least, this was my thought pattern. Let me know if I should be doing something different. @pnrobinson

pnrobinson commented 5 years ago

I think Abn circulating long-chain fatty acid... is better. Arachidonate is metabolised to an eicosanoid, but I do not think it is itself one. Added as HP_0020197 @callahantiff