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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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Renal interstitial inflammation #5060

Closed pnrobinson closed 4 years ago

pnrobinson commented 4 years ago

Definition:Inflammation involving fibrotic as well as non-fibrotic renal cortex, composed of lymphocytes, monocytes, plasma cells

nicolevasilevsky commented 4 years ago

We could use this pattern: https://github.com/obophenotype/upheno/blob/master/src/patterns/dosdp-dev/abnormallyIncreasedOccurrenceOfBiologicalProcessInLocation.yaml

GO_0006954 'inflammatory response' UBERON_0005270 'renal cortex interstitium'

pnrobinson commented 4 years ago

@avizrosenberg Is this synonymous with label: tubulointerstitial nephritis syn: interstitial nephritis, Renal interstitial inflammation

I am also wondering about the definition, which mentions "cortex" but that is not the same as "interstitial". I would suggest: Def: An immune-mediated infiltration of the kidney interstitium by inflammatory cells, composed of lymphocytes, monocytes, plasma cells citation: https://www.ncbi.nlm.nih.gov/pubmed/27155873/

Comment: Tubulointerstitial nephritis can lead to non-oliguric or oliguric acute kidney injury

avizrosenberg commented 4 years ago

@pnrobinson interstitial inflammation can result in nephritis which is a functional implication. However, inflammation can be associated with scar or other reactive process and in and of itself not be driving a functional decline. Regarding cortex vs medulla, we spend much of our time as renal pathologists in the cortex however, inflammation of significance can occur in the medulla as well, so the definition can be altered to reflect this.

pnrobinson commented 4 years ago

add two child terms for cortical and medulla