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Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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Accumulation of hemosiderin laden macrophages #5558

Closed mgriese closed 4 years ago

mgriese commented 4 years ago

Preferred term label: Accumulation of hemosiderin laden macrophages

Synonyms

Definition (free text, please give PubMed ID) Erythrocyte fragments are found in the macrophages, leading to the diagnosis of previous pulmonary hemorrhage. Costabel U. Atlas of bronchoalveolar lavage. London: Chapman & Hall; 1998. ISBN0412792702.

Parent term (use hpo.jax.org/app) Abnormalities of alveolar macrophages

Diseases characterized by this term ? (e.g. Orphanet or OMIM number)

Your nano-attribution (ORCID) @GrieseAG @Katrinknoflach

GrieseAG commented 4 years ago

Diseases characterized by this term? same as in Pulmonary hemorrhage HP:0040223 ORPHA:520, OMIM:616414, OMIM:603585, ORPHA:183, OMIM:233450, ORPHA:900, ORPHA:79124, ORPHA:363611, ORPHA:509, OMIM:222700, ORPHA:2038, OMIM:178550, ORPHA:238459, ORPHA:906,

GrieseAG commented 4 years ago

Definition: Hemosiderin-laden macrophages (HLM) in bronchoalveolar lavage (BAL) fluid were originally known as adiagnostic biomarker of alveolar hemorrhage, but have also been observed in idiopathic pulmonary fibrosis (IPF) with histopathological pattern of usual interstitial pneumonia (UIP).

Comment: Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen.

PMID: 23678356, 28166761

pnrobinson commented 4 years ago

added as HP:0032979