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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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Obstructive lung disease (HP: 0006536) > Reduced FEV1/FVC ratio HP:0030877 #5570

Closed GrieseAG closed 4 years ago

GrieseAG commented 4 years ago

HPO term Obstructive lung disease (HP: 0006536)

Reason for deprecation Obstructive lung disease is a more a general term and describes a disease not a single characteristic feature.

Suggested replacement or term to consider Airflow obstruction is typically assessed by spirometry. Individuals with airflow obstruction have reductions in the forced expiratory volume at 1 s (FEV1) and in the ratio of FEV1 to forced vital capacity (FVC). Can be described by existing HPO terms: Reduced FEV1/FVC ratio (HP:0030877), Reduced forced expiratory volume in one second (HP:0032342), additional features are Chronic bronchitis (HP:0004469), Emphysema (HP:0002097)

terms can be linked to disease via OMIM: 606963 (COPD), 613490 (Alpha 1 Antitrypsin deficiency), and to genetic associations (SERPINA1 OMIM:107400, TGFB1 OMIM: 190180)

PubMed: 15175276, 11914989

nano-attribution LMU crapp, @mgriese, @katrinknoflach

pnrobinson commented 4 years ago

Label -- Chronic pulmonary obstruction

pnrobinson commented 4 years ago

relabeled.

pnrobinson commented 4 years ago

done