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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: 'diffuse alveolar damage' #5626

Closed paolaroncaglia closed 4 years ago

paolaroncaglia commented 4 years ago

(Relevant for COVID19 studies) Hi, as discussed with @matentzn , could you please add:

Preferred term label: diffuse alveolar damage

Synonyms Acronym (non-exact synonym): DAD

Definition (free text, please give PubMed ID) An acute lung condition with the presence of hyaline membranes, made up of dead cells, surfactant, and proteins, and deposited along the walls of the alveoli, where gas exchange typically occurs, thereby making gas exchange difficult. PMID:32364264 PMID:28570160 Wikipedia:Diffuse_alveolar_damage

Parent term (use hpo.jax.org/app) HP:0002088 Abnormal lung morphology (not sure if a more specific parent exists)

Diseases characterized by this term ? (e.g. Orphanet or OMIM number) Not sure

Your nano-attribution (ORCID) 0000-0003-0800-544X 0000-0002-2825-0621

Note, this is different from HP:0025420 'Diffuse alveolar hemorrhage'. In fact, the def of that term says "...Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen.". Not sure if the two terms should be related in any way.

Thanks!

matentzn commented 4 years ago

@pnrobinson is it ok if we add this term?

pnrobinson commented 4 years ago

@mgriese, @katrinknoflach could you please comment?

pnrobinson commented 4 years ago

My initial feedback is that we do not observe "damage". The HPO tries to record the actual observed abnormalities. "damage" is our description of the consequence of these abnormalities. It would be better to describe these more precisely.

mgriese commented 4 years ago

Suggest Definition DAD describes a histologic finding in the lung which includes dead cells, hyaline membrane made of surfactant and proteins filling the alveoli. This results in impaired gas exchange. The corresponding clinical entity is ARDS. DAD may result from pulmonary drug toxicity.

I´ll comment later on diseases linked.

paolaroncaglia commented 4 years ago

Meanwhile, thank you both @pnrobinson and @mgriese for following up on this.

mgriese commented 4 years ago

Extending the definition a little bit and adding diseases associated:

Definition DAD describes a comon histologic injury pattern of the lung. The early stages are characterized by epithelial cells necrosis and sloughing, fibrious exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is ARDS. DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis and crack cocaine inhalation.

By the way, my ORCID number is: 0000-0003-0113-912X

pnrobinson commented 4 years ago

Adding as HP:0033006, thanks!