Definition (free text, please give PubMed ID)
The presence of autoantibodies in the serum that react to the glomerular basement membrane.
Comment: Anti-GBM-antibodies are found in Goodpasture syndrome. Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveoli) resulting in bleeding of the lung (pulmonary hemorrhage).
Parent term (use hpo.jax.org/app)
Autoimmune antibody positivity HP:0030057
Diseases characterized by this term ? (e.g. Orphanet or OMIM number)
Goodpasture Syndrome OMIM:233450
ORPHA:375 (Disorder) Anti-glomerular basement membrane disease
Your nano-attribution (ORCID)
lmu: chrapp, @katrinknoflach, @mgriese
pnrobinson
commented
4 years ago
Preferred term label: Anti-GBM-antibody positivity
Synonyms Anti-glomerular basement membrane-antibody
Definition (free text, please give PubMed ID) The presence of autoantibodies in the serum that react to the glomerular basement membrane.
Comment: Anti-GBM-antibodies are found in Goodpasture syndrome. Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveoli) resulting in bleeding of the lung (pulmonary hemorrhage).
Parent term (use hpo.jax.org/app) Autoimmune antibody positivity HP:0030057
Diseases characterized by this term ? (e.g. Orphanet or OMIM number) Goodpasture Syndrome OMIM:233450 ORPHA:375 (Disorder) Anti-glomerular basement membrane disease
Your nano-attribution (ORCID) lmu: chrapp, @katrinknoflach, @mgriese