Closed GrieseAG closed 4 years ago
definition: Hypersensitivity pneumonitis involves inhalation of an organic antigen. This leads to an exaggerated immune response with inflammation of the alveoli, i.e. alveolitis or pneumonitis. Histopathology of lung biopsies shows a lymphocytic infiltrate of the interstitium, occasional multinucleated giant cells or loose (non-caseating) granuloma. 4-12 h after exposure to the provoking antigen fever, chills, malaise, cough, hemoptysis, chest tightness, dyspnea, rash, swelling and headache can occur. With removal of the antigen this is reversible, with continous expose lung fibrosis occurs. Acute (HP:0011009), subacute (HP:0011011), and chronic (HP:0011010) Hypersensitivity pneumonits may be differentiated. PMID: 23924322, PMID: 27836954.
Comment: Hypersensitivity pneumonitis is the general term. Based on the provoking antigen many different specifying terms are used. PMID 16635083, PMID 15316440, PMID 18051218. Grouped according to the source of antigen, exampels are:
Bacteria: Thermophilic actinomycetes => Farmers lung; bagasse worker
s lung; mushroom workers lung, potato riddler
s lung, compost workers lung, ventilation system
s lung; Lichtheimia corymbifera => Farmers lung; Acinetobacter, Ochrobactrum => Metal working fluid
s lung; Streptomyces albus => Compost workers lung; Klebsiella oxytoca=> Humidifier
s lung; Bacillus subtilis enzymes => Detergent industry lung; Mycobacterium avium complex and other nontuberculous mycobacteria => Spa workers lung. Mycobacterium immunogenum => Metal working fluid
s lung, machine operator´s lung.
Fungi: Alternaria alternate => Humidifiers lung, wood worker
s lung; Aspergillus spp. => Stucco workers lung, tobacco grower
s lung, malt workers lung; Trichosporon cutaneum => Summer‐type HP; Penicillium glabrum=> Cork worker
s lung; Pencillium roqueforti => Cheese workers lung; Penicillium verrucosum => Food processor
s lung; Penicillium camemberti => Food processors lung; Penicillium citreonigrum => Peat moss processing worker
s lung; Cryptostroma corticale => Maple bark strippers lung, florist
s lung; Botrytis cinerea => Wine makers lung; Mucor stolonifera => Paprika slicer
s lung; Rhodotorula => Humidifiers lung. Mushrooms: Shiitaki, Bunashimeji, Pleurotus, Pholiota, Shimeji, Agaricus => Mushroom worker
s lung.
Enzymes: Phytase, subtilisin => Animal feeding lung, cleaners lung. Animal & insect proteins: Avian serum and feather proteins => Bird breeder
s lung; Rat serum proteins= > Laboratory workers lung; Pearl => Pearl industry lung; Mollusk shell => Nacre industries’ lung; Silk => Textile worker
s lung; Carmine => Food and cosmetic industries’ lung; Sitophilus granaries => Farmers lung. Plant proteins: Tiger nut => Food processor
s lung; Legumes (e.g. soy) => Food processors lung; Malt => Food processor
s lung; Alginate => Seaweed workers lung. Woods: Ramin, pine => Wood worker
s lung, Esparto dust => Stucco workers lung Low molecular weight chemicals: Diisocyanates => Chemical and polyurethane industry, painter
s lung; Acid anhydrides => Plastic workers lung, aircraft industries’ lung; Acrylate compounds = > Dental technician
s lung; Triglycidyl isocyanurate => Painters lung (powder paint) Pharmaceutical agents: penicillins, cephalosporins => Pharmaceutical industry’s lung; Dimethyl phthalate and styrene => Yacht manufacturing lung Metals: Cobalt => Hard‐metal worker
s lung; Zinc => Smelters lung; Zirconium => Ceramic worker
s lung.
=> I suggest to make a term for each "disease"
@mgriese we would add diseases to Mondo, not HPO.
@pnrobinson and @cmungall any objections to adding these diseases to Mondo?
It looks like we have a few of them already:
I will make a ticket in Mondo
@nicolevasilevsky @GrieseAG @cmungall I agree that we should add the subtypes to MONDO. The HPO term can remain to refer to the typical phenotypic manifestation, although in the fullness of time we need to link this to the Mondo term as well. @nicolevasilevsky Please close this issue as soon as we have linked to MONDO!
I have linked this to the Mondo tracker, closing here. (https://github.com/monarch-initiative/mondo/issues/1821)
HPO term Hypersensitivity pneumonitis HP:0006516
Synonym to be added exogen allergic alveolitis, extrinsic allergic alveolitis
broad/exact/narrow/plural/abbreviation ? EAA
definition: Hypersensitivity pneumonitis involves inhalation of an antigen. This leads to an exaggerated immune response and a following inflammation of the alveoli within the lungs. The main feature of chronic hypersensitivity pneumonitis on lung biopsies is expansion of the interstitium by lymphocytes accompanied by an occasional multinucleated giant cell or loose granuloma. After exposure to the provoking antigen, following symptoms can be seen: fever, chills, malaise, cough, hemoptysis, chest tightness, dyspnea, rash, swelling and headache and can be completely reversible, based on the duration of the illness, categorized as acute (HP:0011009), subacute (HP:0011011), and chronic (HP:0011010).
Comment: Hypersensitivity pneumonitis may also be called many different names, based on the provoking antigen PMID 16635083, PMID 15316440, PMID 18051218
nano contribution lmu: chrapp, @katrinknoflach, @mgriese