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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR, pulmo: Neuroepithelial bodies in the alveolar ducts #6391

Closed GrieseAG closed 3 years ago

GrieseAG commented 3 years ago

Preferred term label: Presence of neuroepithelial bodies in the alveolar ducts

Synonyms

Definition (free text, please give PubMed ID) Presence of bombesin-immuno-positive neuroendocrine cell cluster (neuroepithelial bodies) in the alveolar ducts.

Parent term (use hpo.jax.org/app) Interstitial pulmonary abnormality HP:0006530

Diseases characterized by this term ? (e.g. Orphanet or OMIM number) NEHI ORPHA:217560

Your nano-attribution (ORCID) LMU:chrapp, @kknoflach, @mgriese

pnrobinson commented 3 years ago

@mgriese can we define better what is the abnormality? Pulmonary neuroepithelial bodies (NEB) in mammalian lungs are thought to function as airway O2 sensors that release serotonin (5-HT) in response to hypoxia. So where are the NEB normally located? Why is the alveolar duct location abnormal?

pnrobinson commented 3 years ago

Label: Increased airway neuroepithelial bodies

pnrobinson commented 3 years ago

added