Glomerular proteinuria

[johannaest]

Preferred term label: Glomerular proteinuria

Synonyms

Definition (free text, please give PubMed ID) Proteinuria wih an increased permeability of the glomerular capillary wall to macromolecules (particularly albumin). PMID: 19634399

Parent term (use hpo.jax.org/app) Proteinuria

[pnrobinson]

@avizrosenberg @yongqunh -- can you please comment?

@johannaest -- the HPO does not encode pathophysiology -- it is limited to observable phenotypes. I do not think that if you are measuring protein in urine it is clearly possible to differentiate, except that severe proteinuria is usually glomerular. The HPO currently has terms for mild, moderate, severe proteinuria, and I believe these are the actual phenotypic features (observations).

Therefore, probably this is not a good candidate for an HPO term, but if I am missing something please respond!

[yongqunh]

I feel that it's difficult to define "observable phenotypes". For example, the lab test results cannot be observed by eyes directly and will need to be tested using lab test. Similarly, protein levels cannot be observed directly but can by some experimental test. I think it's probably fine to have encode pathophysiological phenotypes, depending on how to define "observable".

[johannaest]

​Hello everyone,

I agree with Oliver. There are already other HPO terms that are not phenotypic observable for example Methemoglobulinemia. This is a lab test result. It is difficult to differentiate here.​

Best,

Johanna

 

Von: Yongqun Oliver He notifications@github.com Gesendet: Mittwoch, 2. Dezember 2020 20:01 An: obophenotype/human-phenotype-ontology Cc: Est, Johanna Ligaya; Mention Betreff: Re: [obophenotype/human-phenotype-ontology] Glomerular proteinuria (#6399)  

I feel that it's difficult to define "observable phenotypes". For example, the lab test results cannot be observed by eyes directly and will need to be tested using lab test. Similarly, protein levels cannot be observed directly but can by some experimental test. I think it's probably fine to have encode pathophysiological phenotypes, depending on how to define "observable". — You are receiving this because you were mentioned. Reply to this email directly, view it on GitHub, or unsubscribe.

[pnrobinson]

@yongqunh @johannaest -- by observable I mean measurable, not necessarily observable with our eyes.

There are phenotypic differences between tubuluar and glomerular proteinuria, e.g. Unlike glomerular proteinuria, where protein excretion can reach 20 g/24 h and consists mainly of albumin, tubular proteinuria is generally < 1–2 g/24 h. In tubular proteinuria, although albumin remains a significant component, there is a relatively much greater increase in proteins of < 60 000 Da @avizrosenberg -- is there a recommendation about how to classify proteinuria like this?

[avizrosenberg]

the major difference between glomerular and tubular protein is in the composition of the protein. One typically has a significant albumin component in glomeuralr proteinuria compared with b2 Microglobulin in tubular protein. This is all in contrast to other phenotypes wherein there may be a paraprotein (i.e., light chains)

[yongqunh]

There is a typo in the definition: "Proteinuria wih an increased permeability" --> "Proteinuria with an increased permeability " otherwise, looks good to me.

The definition appears to be aligned with the description in the paper (PMCID: PMC4953623, PMID: 19634399) copied: "Glomerular proteinuria Glomerular disease causes an increase in the permeability of the glomerular capillary wall to macromolecules (particularly albumin) and results in glomerular proteinuria. It is persistent and may be associated with haematuria and reduced GFR." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4953623/

[pnrobinson]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC322340/

[yongqunh]

It appears to be a good reference!

[pnrobinson]

added