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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR, pulmo: polyalveolar lobe #6435

Closed GrieseAG closed 3 years ago

GrieseAG commented 3 years ago

Preferred term label: polyalveolar lobe

Synonyms Increased number of alveoli

Definition (free text, please give PubMed ID) In polyalveolar lobe, the total alveolar number as determined by microscopic point-counting of randomly taken lung sections is increased three to fivefold. The airways and arteries are normal for age in number, size and structure.

Comment: All patients have some pulmonary function abnormalities, specifically a decrease in airway conductance, and forced expiratory volume. PMID: 7463297

Parent term (use hpo.jax.org/app) Abnormal pulmonary alveolar system morphology HP:0033137

Diseases characterized by this term ? (e.g. Orphanet or OMIM number) ORPHA:1928 (Disorder) Congenital lobar emphysema

Your nano-attribution (ORCID) lmu: chrapp, @kknoflach, @mgriese

pnrobinson commented 3 years ago

I have slightly reworded the definition

An elevation of the total count of alveoli as determined by microscopic point-counting of randomly taken lung sections, not secondary to abnormalities in number, size and structure of the airways. In polyaveolar lobe, the number of alveoli is generally increased three to fivefold.

please reopen this issue if the revised definition is incorrect. @chrapp, @kknoflach, @mgriese