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Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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Abnormal alveolar volume (VA) #6499

Closed eswietlik closed 3 years ago

eswietlik commented 3 years ago

Preferred term label: Abnormal alveolar volume (VA)

Synonyms

Definition (free text, please give PubMed ID) Alveolar volume (VA) is a volume accessible during 10-second breath-hold, measured during a single breath manoeuvre. VA is calculated by knowing the fractional concentration of the tracer gas (eg helium) and the volume of the gas inhaled. VA = Vi x(Fi tracer/Fa tracer); Vi - inspired volume of tracer gas, Fi tracer- inspired fraction of tracer gas, Fa tracer - alveolar (exhaled) fraction of tracer gas. PMID 28049168

Parent term (use hpo.jax.org/app) Abnormality in pulmonary function testing HP:0030878

Diseases characterized by this term? (e.g. Orphanet or OMIM number) Pleural mesothelioma ORPHA:50251 Pleural empyema ORPHA:449266 Idiopathic pulmonary fibrosis ORPHA:2032 Congenital lobar emphysema ORPHA:1928 Combined pulmonary fibrosis-emphysema syndrome ORPHA:300564

Your nano-attribution (ORCID) https://orcid.org/0000-0002-4095-8489

pnrobinson commented 3 years ago

@eswietlik could you provide a definition of alveolar volume -- especially, how is it different from other measures of lung volume such as TLC? I have not been able to find a review article on this topic.

eswietlik commented 3 years ago

@pnrobinson VA term definition and citation now updated

pnrobinson commented 3 years ago

add increased/decreased

pnrobinson commented 3 years ago

@eswietlik adding this comment to provde context Only a portion of each tidal volume (Vt) reaches the alveoli and participates in gas exchange. This is referred to as the alveolar volume (Va). The remainder, the so-called dead space volume (Vd), consists of gas that fills the upper and lower airways (anatomic dead space) or reaches nonperfused or relatively poorly perfused alveoli (alveolar dead space).