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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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Pulmonary artery intimal thickening #6519

Closed eswietlik closed 3 years ago

eswietlik commented 3 years ago

Preferred term label: Pulmonary artery intimal thickening

Synonyms

Definition (free text, please give PubMed ID) Relative intima thickness to the thickness of the vessel wall > 10% (PMID: 28025704)

Parent term (use hpo.jax.org/app) Abnormal pulmonary artery morphology HP:0030966

Diseases characterized by this term? (e.g. Orphanet or OMIM number)

Idiopathic pulmonary arterial hypertension ORPHA:275766 Hereditary pulmonary arterial hypertension ORPHA:275777

Your nano-attribution (ORCID) https://orcid.org/0000-0002-4095-8489

pnrobinson commented 3 years ago

@eswietlik I would revise the define as follows to provode more context for non-specialists def: Increased thickness of the intimal layer of the pulmonary artery. Throughout the pulmonary arterial tree, the thin intima consists of a non-fenestrated monolayer of endothelial cells lining the vessel lumen, as well as a sub-endothelial interstitium that extends to the internal elastic lamina. Intimal thickness in human lung ranges from 1-16% of total wall thickness. Pulmonary artery intimal thickening can be defined as a relative intima thickness to the thickness of the vessel wall of over 10% (PMID: 28025704 PMID: 23606929

OK?

pnrobinson commented 3 years ago

added