Closed eswietlik closed 3 years ago
I think a better definition is
Increased amount of collagen, proteoglycans, and other extracellaulr matrix proteins resulting in scarring and thickening in the adventia of the pulmonary artery. (Question -- do we actually mean the pulmonary arterial tree rather than just the pulmonary artery sensu strictu? Should we cite this article for additional context: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039811/).
Agree, sorry, was rushing through it and did not finish the definition. Yes, the adventitial fibrosis affects a significant proportion of pulmonary arterial tree (rather than just main, R and L PAs) and plays a significant role in disease pathogenesis PMID: 17008597; PMID: 23737168
adding term, thanks!
Preferred term label: Pulmonary artery adventitial fibrosis
Synonyms
Definition (free text, please give PubMed ID) Accumulation of the fibroblasts in the adventitia PMID: 23737168
Parent term (use hpo.jax.org/app) Abnormal pulmonary artery morphology HP:0030966
Diseases characterized by this term? (e.g. Orphanet or OMIM number)
Idiopathic pulmonary arterial hypertension ORPHA:275766 Hereditary pulmonary arterial hypertension ORPHA:275777 Pulmonary arterial hypertension associated with congenital heart disease
Your nano-attribution (ORCID) https://orcid.org/0000-0002-4095-8489