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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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HP:0025658 and HP:0025715, potential duplicates #7332

Closed grahamponting closed 2 years ago

grahamponting commented 2 years ago

Hi Peter,

HP:0025658 Abnormal umbilical artery Doppler pattern in pregnancy HP:0025715 Abnormal umbilical artery doppler waveform during pregnancy

These two new concepts both refer to abnormalities in umbilical artery Doppler waveform during pregnancy, and on the face of it, are very similar, and I can't see any difference between the two. Many thanks. Graham Ponting

pnrobinson commented 2 years ago

@sparkste can we touch bases about the umbilical artery terms? Are the following synonyms (and thus should be merged)? Do we need additional detail about pathological umbilical artery Doppler patterns? Abnormal umbilical artery Doppler pattern in pregnancy HP:0025658 and Abnormal umbilical artery doppler waveform during pregnancy HP:0025715

sparkste commented 2 years ago

Hi all,

Yes, I agree that "abnormal umbilical artery Doppler pattern in pregnancy" and "abnormal umbilical artery Doppler waveform during pregnancy" are synonyms.

We typically describe UA Dopplers as: 1) normal umbilical artery Dopplers, 2) elevated umbilical artery Dopplers, 3) absent end diastolic flow in umbilical artery Dopplers, and 4) reversed flow in umbilical artery Dopplers. Numbers 2-4 would all technically fall under "abnormal" UA Dopplers.

Does this help? Let me know if you want further clarification!

Teresa

Teresa Sparks, MD, MAS

Maternal Fetal Medicine and Clinical Genetics

Department of Obstetrics, Gynecology, & Reproductive Sciences

University of California, San Francisco

From: Peter Robinson @.> Sent: Saturday, February 26, 2022 4:02 AM To: obophenotype/human-phenotype-ontology @.> Cc: Sparks, Teresa @.>; Mention @.> Subject: Re: [obophenotype/human-phenotype-ontology] HP:0025658 and HP:0025715, potential duplicates (Issue #7332)

@sparkste can we touch bases about the umbilical artery terms? Are the following synonyms (and thus should be merged)? Do we need additional detail about pathological umbilical artery Doppler patterns? Abnormal umbilical artery Doppler pattern ZjQcmQRYFpfptBannerStart This Message Is From an External Sender This message came from outside your organization. ZjQcmQRYFpfptBannerEnd

@sparkstehttps://urldefense.com/v3/__https://github.com/sparkste__;!!LQC6Cpwp!6PaAx_DZ4-2sDNB2Q4qXjzd3HFJksiNlht__E49AehoLb9CslkOHXhJ9OglTWds0gVo$ can we touch bases about the umbilical artery terms? Are the following synonyms (and thus should be merged)? Do we need additional detail about pathological umbilical artery Doppler patterns? Abnormal umbilical artery Doppler pattern in pregnancy HP:0025658https://urldefense.com/v3/__https://hpo.jax.org/app/browse/term/HP:0025658__;!!LQC6Cpwp!6PaAx_DZ4-2sDNB2Q4qXjzd3HFJksiNlht__E49AehoLb9CslkOHXhJ9OglTIjlL-pk$ and Abnormal umbilical artery doppler waveform during pregnancy HP:0025715https://urldefense.com/v3/__https://hpo.jax.org/app/browse/term/HP:0025715__;!!LQC6Cpwp!6PaAx_DZ4-2sDNB2Q4qXjzd3HFJksiNlht__E49AehoLb9CslkOHXhJ9OglT71LvtZc$

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pnrobinson commented 2 years ago

Thanks, I merged these two terms. I also added three terms as below. @sparkste please reopen this issue if the definitions of the new terms need work.

pnrobinson commented 2 years ago

Reversed end-diastolic umbilical artery flow Def: An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an reversal of flow in the umbilical artery at the end of diastole (i.e., backwards flow).

pnrobinson commented 2 years ago

Absent end-diastolic umbilical artery flow def: An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an absence of flow in the umbilical artery at the end of diastole.

pnrobinson commented 2 years ago

Elevated umbilical artery pulsatility Def: Human umbilical artery (UA) blood flow pulsatility measured by Doppler ultrasound is a widely used biomarker for the detection of elevated placental vascular resistance. Elevated UA pulsatility, which in the most extreme cases manifests as absent or even reversed end-diastolic velocity, is associated with intrauterine growth restriction (IUGR) and still-birth.