NTR: Cardiac Imaging: valvular vegetation (Cardiac & vascular)

pnrobinson commented 1 year ago

New term request Cardiac Imaging: valvular vegetation (brumme_220419183559): Echocardiogram; cardiac ultrasound; intracardiac foreign object; intracardiac mass UMLS: 1399207

pnrobinson commented 7 months ago

@MickeySegal how can we differentiate this from Libman-Sacks lesions HP:0011714, which is perhaps a bit more specific?

MickeySegal commented 6 months ago

We use this finding for various forms of endocarditis (infective (L or R heart) or nonbacterial) and for invasive candidiasis. It would be good to have a general term as a parent of Libman-Sacks.

pnrobinson commented 6 months ago

@MickeySegal Adding new term:

ID: HP:6000326
label: Cardiac valve vegetations
parents: Abnormal heart valve morphology (HP:0001654)
pmid: PMID:17678415
def: Endocarditis infection occurs along the edges of the heart valves. Damage to the cardiac endothelium followed by platelet and fibrin deposition results in a sterile lesion known as nonbacterial thrombotic endocarditis (NBTE) or vegetation. Microbes entering the bloodstream via routine or invasive procedures adhere to the vegetation and are engulfed in an outer meshwork of fibrin and platelets. Subsequent rapid microbial multiplication in a protected area of impaired host defense leads to vegetation growth and continuous bacteremia.
comment:
orcid: orcid:0000-0002-0736-9199
github ID: https://github.com/obophenotype/human-phenotype-ontology/issues/7790
synonyms:

obophenotype / human-phenotype-ontology

NTR: Cardiac Imaging: valvular vegetation (Cardiac & vascular) #7790