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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Maternal age young during pregnancy (General history, localization & modifiers) #7843

Closed pnrobinson closed 8 months ago

pnrobinson commented 1 year ago

New term request Maternal age young during pregnancy (elthat_151204125311): Mother UMLS: 2721699

pnrobinson commented 1 year ago

@MickeySegal what is the definition of young? Can we provide context or a PMID?

MickeySegal commented 1 year ago

All my citations are for books, and I expect to be able to check in a few days when I return.

MickeySegal commented 1 year ago

Typical is the Woodward obstetrics book that says "younger maternal age" as a risk factor in septo optic dysplasia. A literature citation is: https://pubmed.ncbi.nlm.nih.gov/22907285/ "SOD is associated with younger maternal and paternal age, primigravida births and ethnic differences."

pnrobinson commented 8 months ago

@MickeySegal The problem with this term is that the definition of young maternal age is culture-dependent and there is no single cut-off that would be (nearly) universally accepted in the way there is a cutoff for say serum potassium. I do not have access to the article, but from the abstract it looks like a linear regression was performed with maternal age, so there is no obvious way of saying whether a given mother is "too young" or not. I would suggest we not make this an HPO term.