NTR: Ability to taste phenylthiocarbamide low (GI, feeding, vomiting & dehydration)

pnrobinson commented 2 years ago

New term request Ability to taste phenylthiocarbamide low (elthat_130418183903): PTC, thiourea

pnrobinson commented 9 months ago

@MickeySegal we did a biological practicum related to this...memories... But this is more of a trait than a medically relevant phenotypic abnormality? This does not seem to be in scope for HPO?

MickeySegal commented 9 months ago

That is a defensible position. But if a child has an aversion to certain foods and a parent with inability to taste phenylthiocarbamide, one possibility to consider is that the child can taste phenylthiocarbamide and got that gene from the other parent (tasting is dominant), who can serve as a taster to validate instances in which things are distastefully bitter to phenylthiocarbamide tasters. As a taster married to a non-taster, I often serve as such a reality check. In high school, I did a pedigree of my extended family to argue for tolerance of such biological diversity.

And it does have an OMIM entry: https://omim.org/entry/171200

And there are probably other taste differences that are clinically relevant. As part of our https://pubmed.ncbi.nlm.nih.gov/35815177/ research I discovered that I have a much lower threshold for tasting sweetness than others, which may account for my ease in avoiding obesity more than any abstract characteristics such as willpower.

pnrobinson commented 4 months ago

@MickeySegal interesting. I also seem to have an anti-craving for sweat foods, although with slightly less influence on my figure. Still, I think this is outside the scope and also pretty unlikely to be sought after in clinical contexts. Monarch Initiative will be working more on traits, and this is probably where this item would go.

obophenotype / human-phenotype-ontology

NTR: Ability to taste phenylthiocarbamide low (GI, feeding, vomiting & dehydration) #7880