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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Rabies virus RT-PCR positive (Lab: bacteriology, virology, parasitology, fungal) #8074

Closed pnrobinson closed 1 month ago

pnrobinson commented 1 year ago

New term request Rabies virus RT-PCR positive (samant_110131003557): Reverse transcriptase polymerase chain reaction; RNA UMLS: 3687179

pnrobinson commented 3 months ago

@MickeySegal what is the tissue in which the test is being performed?

MickeySegal commented 3 months ago

https://www.cdc.gov/rabies/php/laboratories/diagnostic.html "The LN34 PCR test for rabies is a newer diagnostic test that uses real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR) methodology to detect the presence of rabies virus genetic material.

The best tissue for rabies testing by any test is the brain, and rabies rule-out by the LN34 test requires a full cross-section of the brainstem and representative samples from the cerebellum. Skin biopsy from the nape of the neck and saliva samples can be tested by LN34 to detect rabies in suspect antemortem human rabies cases. This innovative test targets a highly conserved region of the virus genome including the leader region and nucleoprotein gene, which ensures robust detection across all viruses that can cause rabies."

pnrobinson commented 2 months ago

@MickeySegal Adding new term:

MickeySegal commented 2 months ago

The use of brain tissue seems to be only postmortem. I'd prefer this to be saliva as described in the quote above.

pnrobinson commented 1 month ago

@MickeySegal

Adding new term: