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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Pancreatic secretory trypsin inhibitor high in blood (Lab: blood chemistry: enzymes) #8180

Closed pnrobinson closed 1 year ago

pnrobinson commented 1 year ago

New term request Pancreatic secretory trypsin inhibitor high in blood (segal_051020155928): PSTI UMLS: 3276179

pnrobinson commented 1 year ago

Label: Elevated circulating pancreatic secretory trypsin inhibitor activity Synonyms: Elevated circulating serine protease inhibitor Kazal type I Elevated circulating SPINK1 activity Definition: Increased activity of the enzyme pancreatic secretory trypsin inhibitor in the blood circulation. Comment: Pancreatic secretory trypsin inhibitor (PSTI), also known as serine protease inhibitor Kazal type I (SPINK1), binds rapidly to trypsin, inhibits its activity and is likely to protect the pancreas from prematurely activated trypsinogen. The blood concentration of PSTI may be increased in hepatocellular carcinoma and as a part of the acute phase reposnse response to infection, inflammation, tissue damage and other stressors. PMID:21607145

pnrobinson commented 1 year ago

@MickeySegal added as HP:0034545