NTR: Cholesterol sulfate high in blood (Lab: blood chemistry)

@MickeySegal Adding new term:

ID: HP:6000565
label: Elevated circulating cholesterol sulfate concentration
parents: Abnormal circulating cholesterol concentration (HP:0003107)
pmid: PMID:12730293
def: The concentration of cholesterol sulfate in the blood circulation is above the upper limit of normal.
comment: holesterol sulfate is quantitatively the most important known sterol sulfate in human plasma. Cholesterol sulfate is a component of cell membranes where it has a stabilizing role, e.g., protecting erythrocytes from osmotic lysis and regulating sperm capacitation. It is present in platelet membranes where it supports platelet adhesion. Cholesterol sulfate can regulate the activity of serine proteases, e.g., those involved in blood clotting, fibrinolysis, and epidermal cell adhesion. As a result of its ability to regulate the activity of selective protein kinase C isoforms and modulate the specificity of phosphatidylinositol 3-kinase, cholesterol sulfate is involved in signal transduction.
orcid: orcid:0000-0002-0736-9199
github ID: https://github.com/obophenotype/human-phenotype-ontology/issues/8258
synonyms:

obophenotype / human-phenotype-ontology