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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Adipic acid high in urine (Lab: chemistry: organic acids) #8599

Open pnrobinson opened 1 year ago

pnrobinson commented 1 year ago

New term request Adipic acid high in urine (segal_030513144143): Dicarboxylic acid, adipate; hexanedioic UMLS: 4315767

pnrobinson commented 1 year ago

@MickeySegal I suspect that this is a synonym of Alpha-aminoadipic aciduria HP:0410309. See also adipic acid. Can you provide more context?

MickeySegal commented 1 year ago

https://www.ncbi.nlm.nih.gov/books/NBK1424/ and https://www.ncbi.nlm.nih.gov/books/NBK558236/ and https://www.ncbi.nlm.nih.gov/books/NBK570205/ specify just adipic. So it seems that the alpha amino form is built on this.

pnrobinson commented 1 week ago

@MickeySegal I think these are actually the same compound. This is what GPT has to say

Adipic acid and alpha adipic acid refer to the same chemical compound. The term "adipic acid" is the standard name for this substance, and it is widely recognized and used in chemical nomenclature. Here's a detailed explanation:

The term "alpha adipic acid" is not commonly used in chemistry and does not refer to a different compound. It seems to be a misnomer or a confusion with other nomenclature conventions. Possible Confusion: In organic chemistry, the prefix "alpha" (α) is sometimes used to denote the position of a substituent relative to a functional group, typically referring to the first carbon atom adjacent to the functional group. However, in the case of adipic acid, such a designation is unnecessary and not used.

MickeySegal commented 5 days ago

This is a classic example of ChatGPT misunderstanding the question and giving an answer that sounds authoritative but is completely tangential to the query.

Wikipedia is more helpful here, showing the structures: https://en.wikipedia.org/wiki/Adipic_acid https://en.wikipedia.org/wiki/%CE%91-Aminoadipic_acid

As expected from the name, alpha amino adipic acid has an amino group added to adipic acid.

This is why people striving to do medical diagnosis accurately should depend on you and me and the information we curate and not on ChatGPT.