NTR: 4-hydroxyphenylactic acid high in urine (Lab: chemistry: organic acids)

pnrobinson commented 1 year ago

New term request 4-hydroxyphenylactic acid high in urine (segal_050105154527): Aciduria UMLS: 1841664

pnrobinson commented 4 months ago

Is this intended to be a xenobiotic? What is the disease context? https://en.wikipedia.org/wiki/4-Hydroxyphenylacetic_acid

pnrobinson commented 1 week ago

@MickeySegal updates?

MickeySegal commented 1 week ago

https://omim.org/entry/140350 Her urine contained large amounts of 4-hydroxyphenylpyruvic acid, 4-hydroxyphenylactic acid, and 4-hydroxyphenylacetic acid.

pnrobinson commented 6 days ago

@MickeySegal

Adding new term:

ID: HP:6001004
label: Elevated urine hydroxyphenyllactic acid level
parents: Abnormal urinary non-proteinogenic amino acid level (HP:0034027)
pmid: PMID:4720815
def: The amount of hydroxyphenyllactic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
comment: Hydroxyphenyllactic acid or 4-hydroxyphenyllactate (the L-form) is a tyrosine metabolite. The level of L-hydroxyphenyllactic acid is elevated in patients with a deficiency of the enzyme p-hydroxyphenylpyruvate oxidase (EC 1.14.2.2).
orcid: orcid:0000-0002-0736-9199
github ID: https://github.com/obophenotype/human-phenotype-ontology/issues/8626
synonyms:

MickeySegal commented 5 days ago

I agree on the fixed spelling.

obophenotype / human-phenotype-ontology

NTR: 4-hydroxyphenylactic acid high in urine (Lab: chemistry: organic acids) #8626