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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Liver biopsy: adenocarcinoma (Lab: pathology: biopsies & morphology) #9123

Closed pnrobinson closed 2 months ago

pnrobinson commented 1 year ago

New term request Liver biopsy: adenocarcinoma (elthat_100428052910): Hepatic biopsy UMLS: 0948680

pnrobinson commented 8 months ago

@MickeySegal can you specify which cancer is meant? I do not find an exact match in NCIT https://www.ebi.ac.uk/ols4/ontologies/ncit/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FNCIT_C8609?lang=en

MickeySegal commented 7 months ago

https://www.ncbi.nlm.nih.gov/books/NBK1402/ refers to "Malignancies reported in individuals with HIGM1 include neuroendocrine tumors of the GI tract, colon cancer, bile duct carcinomas, hepatocellular carcinomas, hepatoma, adrenal adenomas, and adenocarcinomas of the liver and gall bladder [[Hayward et al 1997], [Winkelstein et al 2003], [Filipovich & Gross 2004], [Erdos et al 2008], [Leven et al 2016], [Nicolaides & de la Morena 2017]]."

pnrobinson commented 2 months ago

@MickeySegal I cannot find any other reference to this. The "adeno" refers to a gland, and the liver itself does not have a gland outside of the bile system, so I am guessing that this reference is incorrect. The following term is a kind of adenocarcinoma of the bile system: Cholangiocarcinoma HP:0030153

MickeySegal commented 2 months ago

Agree, though UMLS has https://www.ncbi.nlm.nih.gov/medgen/C0948680. I merged this finding into Cholangiocarcinoma.