NTR: Brain biopsy: globoid cells in white matter (Lab: pathology: biopsies & morphology)

pnrobinson commented 1 year ago

New term request Brain biopsy: globoid cells in white matter (segal_100513194153): UMLS: 2237952

pnrobinson commented 1 year ago

Multinucleated phagocytes in the cerebral white matter, typically are 10-15 micrometers in diameter, that contain fatty filamentous inclusions that stain positive for periodic acid-Schiff (PAS), which may be phagocytized myelin, as these cells are often found in proximity to sites where demyelination is prominent. Globoid cells have been to thought to originate from CNS resident microglia and/or infiltrating peripheral macrophages. PMID:27638591

pnrobinson commented 3 months ago

@MickeySegal

Adding new term:

ID: HP:6000892
label: White matter globoid cells
parents: Abnormal cerebral white matter morphology (HP:0002500)
pmid: PMID:27638591
def: Multinucleated phagocytes in the cerebral white matter, typically are 10-15 micrometers in diameter, that contain fatty filamentous inclusions that stain positive for periodic acid-Schiff (PAS), which may be phagocytized myelin, as these cells are often found in proximity to sites where demyelination is prominent. Globoid cells have been to thought to originate from CNS resident microglia and/or infiltrating peripheral macrophages.
comment:
orcid: orcid:0000-0002-0736-9199
github ID: https://github.com/obophenotype/human-phenotype-ontology/issues/9130
synonyms:

obophenotype / human-phenotype-ontology

NTR: Brain biopsy: globoid cells in white matter (Lab: pathology: biopsies & morphology) #9130