NTR: Renal biopsy: fibronectin deposits (Lab: pathology: biopsies & morphology)

obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features

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NTR: Renal biopsy: fibronectin deposits (Lab: pathology: biopsies & morphology) #9301

Closed pnrobinson closed 7 months ago

pnrobinson commented 1 year ago

New term request Renal biopsy: fibronectin deposits (elthat_130331035207):

pnrobinson commented 1 year ago

@MickeySegal What part of the kidney are the deposits localized to?

MickeySegal commented 1 year ago

https://www.omim.org/entry/137950 "There were homogeneous PAS-positive deposits in the mesangium and subendothelial space that showed strong immunoreactivity to fibronectin... Electron microscopy showed massive fine granular deposits with a homogeneous distribution. Immunohistochemistry showed positive staining of fibronectin, as well as IgG and fibrinogen, in the mesangium and capillary loop. "

pnrobinson commented 7 months ago

@MickeySegal Adding new term:

ID: HP:6000428
label: Glomerular fibronectin deposits
parents: Glomerular deposits (HP:0030949)
pmid: PMID:35774511
def: Accumulation of fibronectin in the glomerulus.
comment: Fibronectin glomerulopathy (FNG) is characterized by extensive deposition of fibronectin in the glomeruli, especially in the mesangial and subendothelial regions.
orcid: orcid:0000-0002-0736-9199
github ID: https://github.com/obophenotype/human-phenotype-ontology/issues/9301
synonyms: