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obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features
http://obophenotype.github.io/human-phenotype-ontology/
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NTR: Methylphenidate catabolism impaired (Triggers or responses: drugs or treatments) #9499

Open pnrobinson opened 1 year ago

pnrobinson commented 1 year ago

New term request Methylphenidate catabolism impaired (elthat_130622051017): Pharmacokinetics; hydrolysis

pnrobinson commented 4 months ago

@MickeySegal is this a pharmacogenetic finding? I think it would be better to frame it in terms of the affected enzyme activity? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581573/

MickeySegal commented 4 months ago

https://www.omim.org/entry/618057 "Carboxylesterase-1 (114835) is a widely expressed serine esterase that is involved in the hydrolysis of multiple amide-containing and ester-containing endogenous and xenobiotic compounds including therapeutic agents such as methylphenidate..."